This technique can be used in conjunction with laser diffraction to gain a deeper understanding of the sample or to validate the laser diffraction method.
One of the main advantages of automated imaging is that it provides statistically representative distributions by measuring 10’s to 100’s of thousands of particles per measurement. As a result, particle size distribution and particle morphology are determined. Individual particle images are captured from dispersed sample and scanned across sample area underneath the microscope optics while keeping the particles in focus. It can characterize particles ranging from 0.5 microns to several millimeters in size. Malvern Morphologi G3SE - high resolution microscope-based automated imaging system Mastersizer 3000 with dry and wet sample dispersion units This technique provides rapid measurements (several minutes) and repeatability. In laser diffraction a volume distribution is obtained, which shows the volume percentage of particles at a given size obtained. The angular scattering intensity received is then analyzed to calculate the size of the particles responsible for creating the scattering pattern. Laser diffraction works by measuring the angular variation in intensity of light scattered as a laser beam passes through a well dispersed sample. In the case of laser diffraction systems, the particle size reported is the diameter of a sphere that yields an equivalent light scattering pattern as the particle being measured. Malvern Mastersizer 3000 - Laser Diffraction (LD) Refractive index of sample and solvent must be known.Measurements of zeta potential are commonly used to assess the stability of colloidal systems.Ĭoatings, Ceramics, Cosmetics, Cement, Food, Clays Sample Requirements Zeta potential is a physical property which measures electrostatic interaction among particles in suspension. In addition to particle size, the Zetasizer Nano ZS can provide zeta potential values estimated from electrophoretic mobility in aqueous and non-aqueous dispersions using Laser Doppler Micro-Electrophoresis. Zetasizer Nano ZS (Dynamic Light Scattering).Three Malvern instruments are currently available at MCL that are capable of measuring size and shape for particles over a wide size range: Particle characterization instruments at MCL Even small differences can significantly affect material properties such as chemical reactivity, bioavailability, dissolution and crystallization rates, stability in suspension, texture of the material, flow ability and handling, packing density and porosity, to name a few. Particle size and shape are two of the most important physical properties of particulate samples.